Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2.

Christensen, Michael; Schiffer, Tomas A; Gustafsson, Håkan; Krag, Søren Palmelund; Nørregaard, Rikke; Palm, Fredrik

Christensen, Michael; Schiffer, Tomas A; Gustafsson, Håkan; Krag, Søren Palmelund; Nørregaard, Rikke; Palm, Fredrik.

Afiliação

Christensen M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Schiffer TA; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Gustafsson H; Department of Radiology Norrköping and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Krag SP; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
Nørregaard R; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Palm F; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Diabetes Metab Res Rev ; 35(2): e3091, 2019 02.

Article em En | MEDLINE | ID: mdl-30345618

Assuntos

Diabetes Mellitus Experimental/fisiopatologia; Nefropatias Diabéticas/complicações; Hipóxia/prevenção & controle; Medula Renal/efeitos dos fármacos; Metformina/farmacologia; Proteína Desacopladora 2/antagonistas & inibidores; Animais; Nefropatias Diabéticas/patologia; Hipoglicemiantes/farmacologia; Hipóxia/etiologia; Hipóxia/metabolismo; Medula Renal/metabolismo; Medula Renal/patologia; Ratos; Ratos Sprague-Dawley

Palavras-chave

diabetic kidney disease; hypoxia; metformin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Experimental / Nefropatias Diabéticas / Proteína Desacopladora 2 / Medula Renal / Hipóxia / Metformina Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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