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Decorating protein nanospheres with lactoferrin enhances oral COX-2 inhibitor/herbal therapy of hepatocellular carcinoma.
Abdelmoneem, Mona A; Mahmoud, Mazen; Zaky, Amira; Helmy, Maged W; Sallam, Marwa; Fang, Jia-You; Elkhodairy, Kadria A; Elzoghby, Ahmed O.
Afiliação
  • Abdelmoneem MA; Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
  • Mahmoud M; Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
  • Zaky A; Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria 21511, Egypt.
  • Helmy MW; Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria 21511, Egypt.
  • Sallam M; Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
  • Fang JY; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damanhur University, Damanhur 22511, Egypt.
  • Elkhodairy KA; Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
  • Elzoghby AO; Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
Nanomedicine (Lond) ; 13(19): 2377-2395, 2018 10.
Article em En | MEDLINE | ID: mdl-30346255
AIM: Lactoferrin (LF)-targeted gliadin nanoparticles (GL-NPs) were developed for targeted oral therapy of hepatocellular carcinoma. MATERIALS & METHODS: Celecoxib and diosmin were incorporated in the hydrophobic matrix of GL-NPs whose surface was decorated with LF by electrostatic interaction for binding to asialoglycoprotein receptors overexpressed by liver cancer cells. RESULTS: Targeted GL-NPs showed enhanced cytotoxic activity and increased cellular uptake in liver tumor cells compared with nontargeted NPs. Moreover, they demonstrated superior in vivo antitumor effects including reduction in the expression levels of tumor biomarkers and induction of caspase-mediated apoptosis. Ex vivo imaging of isolated organs exhibited extensive accumulation of NPs in livers more than other organs. CONCLUSION: LF-targeted GL-NPs could be considered as an efficient nanoplatform for targeted oral drug delivery for liver cancer therapy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Nanopartículas / Neoplasias Hepáticas / Fitoterapia Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Nanopartículas / Neoplasias Hepáticas / Fitoterapia Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article