First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives.
Molecules
; 23(10)2018 Oct 19.
Article
em En
| MEDLINE
| ID: mdl-30347659
ABSTRACT
Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of ß-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40â»54% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1,4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1,4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored.
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Base de dados:
MEDLINE
Assunto principal:
Di-Hidropiridinas
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Bloqueadores dos Canais de Cálcio
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Catálise
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Compostos Heterocíclicos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article