[Design, synthesis and antiproliferative activity in cancer cells of novel dihydropyrazolyl and pyrazolyl artemisinin-phenyl ethers].
Zhongguo Zhong Yao Za Zhi
; 43(17): 3582-3588, 2018 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-30347929
ABSTRACT
To explore potent anticancer agent based on artemisinin scaffold, a series of 10-O-phenyl ethers derivatives containing dihydropyrazolyl or pyrazolyl moiety have been designed and synthesized. Their structures were determined by LC-MS and ¹H-NMR date. Inhibitory effects of the target compounds in human breast cancer MCF-7, MCF/Adr, MDA-MB-231 cells and prostate cell line PC-3 were determined by MTT assay. Those derivatives displayed good antiproliferative activity against the tested cancer cells. Particularly, target compounds exhibited significant cytotoxicity against drug-resistance cells MCF/Adr, which was worthy for further investigation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Éteres Fenílicos
/
Artemisininas
/
Antineoplásicos
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article