A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017.
Virol J
; 15(1): 163, 2018 10 23.
Article
em En
| MEDLINE
| ID: mdl-30352598
ABSTRACT
BACKGROUND:
In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail.FINDING:
The full-length genome sequence of an HEV-2 strain (NG/17-0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17-0500 belongs to HEV subtype 2b (HEV-2b).CONCLUSIONS:
We identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
RNA Viral
/
Surtos de Doenças
/
Vírus da Hepatite E
/
Hepatite E
/
Genoma Viral
Tipo de estudo:
Prognostic_studies
Limite:
Humans
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article