Growth Factor Delivery Systems for Tissue Engineering and Regenerative Medicine.
Adv Exp Med Biol
; 1078: 245-269, 2018.
Article
em En
| MEDLINE
| ID: mdl-30357627
ABSTRACT
Growth factors (GFs) are often a key component in tissue engineering and regenerative medicine approaches. In order to fully exploit the therapeutic potential of GFs, GF delivery vehicles have to meet a number of key design criteria such as providing localized delivery and mimicking the dynamic native GF expression levels and patterns. The use of biomaterials as delivery systems is the most successful strategy for controlled delivery and has been translated into different commercially available systems. However, the risk of side effects remains an issue, which is mainly attributed to insufficient control over the release profile. This book chapter reviews the current strategies, chemistries, materials and delivery vehicles employed to overcome the current limitations associated with GF therapies.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
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Engenharia Tecidual
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Peptídeos e Proteínas de Sinalização Intercelular
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Medicina Regenerativa
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article