[Study on In Vitro Degradation of Oxidized Regenerated Cellulose Absorbable Hemostatic Products].

OBJECTIVE: To study the in vitro degradation of oxidized regenerated cellulose absorbable hemostatic products. METHODS: The morphology of the oxidized regenerated cellulose hemostatic products before and after degradation was observed by FTIR and SEM. The degradation products were determined by GPC and HILIC-ELSD. RESULTS: In the initial stage of degradation, there was a great change in morphology. GPC determined its degradation end point was 10 d; it was determined that its degradation products contained glucose (0.13%) and cellobiose (0.17%) and other components. CONCLUSIONS: A method was established for determining the end point of degradation of oxidized regenerated cellulose, which provided a new idea and reference for the study of the degradation end point.