Cognition and Vitamin D in Older African-American Women- Physical performance and Osteoporosis prevention with vitamin D in older African Americans Trial and Dementia.
J Am Geriatr Soc
; 67(1): 81-86, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30359476
ABSTRACT
OBJECTIVES:
To examine the effect of 25-hydroxyvitamin D (25(OH)D) levels recommended by Endocrine Society guidelines (>30 ng/mL) on cognition in healthy older African-American women over 3 years.DESIGN:
Randomized, double-blind, placebo-controlled clinical trial.SETTING:
Bone Mineral Research Center at New York University Winthrop Hospital.PARTICIPANTS:
Healthy postmenopausal African American women aged 65 and older (N=260; mean age 68.2 ± 4.9; 46% college education or higher). INTERVENTION Half of the women were randomized to receive vitamin D (adjusted to achieve a serum level > 30 ng/mL) with calcium (diet and supplement total of 1,200 mg), and half were randomized to receive placebo with calcium (1,200 mg). MEASUREMENTS Cognitive assessments every 6 months using the Mini-Mental State Examination (MMSE) to detect cognitive decline. Mean MMSE scores were calculated over time for both groups. Those with MMSE scores less than 21 at baseline were excluded.RESULTS:
The average dose of vitamin D3 was 3,490 ± 1,465 IU per day, and average serum 25(OH)D at 3 years was 46.8 ± 1.2 ng/mL in the active group and 20.7 ± 1.1 ng/mL in the placebo group. Serum 25(OH)D concentration was maintained at greater than 30 ng/mL in 90% of the active group. Over the 3-year period, MMSE scores increased in both groups (p < .001), although change over time was not significantly different between the groups. No adverse events associated with vitamin D were observed.CONCLUSION:
There was no difference in cognition over time between older African-American women with serum concentrations of 25(OH)D of 30 ng/mL and greater than those taking placebo. There is no evidence to support vitamin D intake greater than the recommended daily allowance in this population for preventing cognitive decline. J Am Geriatr Soc 6781-86, 2019.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitaminas
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Negro ou Afro-Americano
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Osteoporose Pós-Menopausa
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Cognição
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Colecalciferol
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Guideline
Limite:
Aged
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Aged80
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Female
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article