PPARα and γ Activation Effects of New Nor-triterpenoidal Saponins from the Aerial Parts of Anabasis articulata.
Planta Med
; 85(4): 274-281, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-30360001
ABSTRACT
Anabasis articulata, traditionally used to treat diabetes, is rich in saponin content. This study was performed to investigate the agonistic effect of its saponins on peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-γ in human hepatoma (HepG2) cells to explore the possibility of the involvement of these nuclear receptors in the mechanism of the antidiabetic effect of the plant. Chemical investigation of the n-butanol fraction resulted in the isolation of three new and one known 30-noroleanane triterpenoid saponins. The structures of the new compounds were elucidated as 3ß-hydroxy,23-aldehyde-30-norolean-12,20(29)-dien-28-oic acid-28-O-ß-D-glucopyranosyl ester (1 ), 3ß-O-D-galactopyranosyl-23-aldehyde-30-norolean-12,20(29)-dien-28-oic acid-28-O-ß-D-glucopyranosyl ester (2 ), and 3ß-O-D-xylopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-ß-D-glucopyranosyl ester (3 ), while the known 30-nortriterpenoidal saponin was identified as boussingoside E (4 ). Although, the isolated saponins (1 â-â4 ) did not show > 1.5-fold activation of peroxisome proliferator-activated receptor-γ, but two of them (1 and 3 ) activated peroxisome proliferator-activated receptor-α to the higher extents of 2.25- and 1.86-fold, respectively. These results suggest that the reported antidiabetic action of the isolated saponins may not solely involve the activation of peroxisome proliferator-activated receptor-γ. However, the agonistic activity of the n-butanol fraction of A. articulata (1.71-fold induction) and two of its saponins (1 and 3 ) towards peroxisome proliferator-activated receptor-α may be beneficial in the cardiovascular condition that is closely associated with diabetes and other metabolic disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Saponinas
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Terpenos
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Extratos Vegetais
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Amaranthaceae
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PPAR alfa
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PPAR gama
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Hipoglicemiantes
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article