Correlations between metabolism and structural elements of the alicyclic fentanyl analogs cyclopropyl fentanyl, cyclobutyl fentanyl, cyclopentyl fentanyl, cyclohexyl fentanyl and 2,2,3,3-tetramethylcyclopropyl fentanyl studied by human hepatocytes and LC-QTOF-MS.

Åstrand, Anna; Töreskog, Amanda; Watanabe, Shimpei; Kronstrand, Robert; Gréen, Henrik; Vikingsson, Svante

Åstrand, Anna; Töreskog, Amanda; Watanabe, Shimpei; Kronstrand, Robert; Gréen, Henrik; Vikingsson, Svante.

Afiliação

Åstrand A; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. anna.astrand@liu.se.
Töreskog A; Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden.
Watanabe S; Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden.
Kronstrand R; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Gréen H; Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden.
Vikingsson S; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Arch Toxicol ; 93(1): 95-106, 2019 01.

Article em En | MEDLINE | ID: mdl-30361799

Assuntos

Analgésicos Opioides/metabolismo; Fentanila/metabolismo; Hepatócitos/metabolismo; Biotransformação; Células Cultivadas; Cromatografia Líquida de Alta Pressão; Fentanila/análogos & derivados; Humanos; Espectrometria de Massas; Estrutura Molecular

Palavras-chave

Fentanyl analogs; Human hepatocytes; LC-QTOF-MS; Metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fentanila / Hepatócitos / Analgésicos Opioides Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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