Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain.

Darreh-Shori, Taher; Rezaeianyazdi, Sareh; Lana, Erica; Mitra, Sumonto; Gellerbring, Anna; Karami, Azadeh; Bogdanovic, Nenad; Lithner, Christina Unger; Winblad, Bengt; Behbahani, Homira

Darreh-Shori, Taher; Rezaeianyazdi, Sareh; Lana, Erica; Mitra, Sumonto; Gellerbring, Anna; Karami, Azadeh; Bogdanovic, Nenad; Lithner, Christina Unger; Winblad, Bengt; Behbahani, Homira.

Afiliação

Darreh-Shori T; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS Department, Karolinska Institutet, Neo7th floor, 141 83, Huddinge, Sweden. taher.darreh-shori@ki.se.
Rezaeianyazdi S; Division of Neurogeriatrics, Center for Alzheimer Research, NVS Department, Karolinska Institutet, 141 83, Huddinge, Sweden.
Lana E; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS Department, Karolinska Institutet, Neo7th floor, 141 83, Huddinge, Sweden.
Mitra S; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS Department, Karolinska Institutet, Neo7th floor, 141 83, Huddinge, Sweden.
Gellerbring A; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS Department, Karolinska Institutet, Neo7th floor, 141 83, Huddinge, Sweden.
Karami A; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS Department, Karolinska Institutet, Neo7th floor, 141 83, Huddinge, Sweden.
Bogdanovic N; Division of Neurogeriatrics, Center for Alzheimer Research, NVS Department, Karolinska Institutet, 141 83, Huddinge, Sweden.
Lithner CU; Neurogeriatric Clinic, Karolinska University Hospital, Center for Alzheimer Research, NVS Department, Karolinska Institutet, Huddinge, Stockholm, Sweden.
Winblad B; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS Department, Karolinska Institutet, Neo7th floor, 141 83, Huddinge, Sweden.
Behbahani H; Division of Neurogeriatrics, Center for Alzheimer Research, NVS Department, Karolinska Institutet, 141 83, Huddinge, Sweden.

Mol Neurobiol ; 56(7): 4601-4619, 2019 Jul.

Article em En | MEDLINE | ID: mdl-30361890

Assuntos

Acetilcolina/metabolismo; Doença de Alzheimer/enzimologia; Encéfalo/enzimologia; Serina Peptidase 2 de Requerimento de Alta Temperatura A/metabolismo; Acetilcolinesterase/genética; Acetilcolinesterase/metabolismo; Idoso; Idoso de 80 Anos ou mais; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Biomarcadores/metabolismo; Encéfalo/patologia; Fator Neurotrófico Derivado do Encéfalo/genética; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Butirilcolinesterase/metabolismo; Feminino; Regulação da Expressão Gênica; Serina Peptidase 2 de Requerimento de Alta Temperatura A/genética; Humanos; Masculino; Pessoa de Meia-Idade; Fator de Crescimento Neural/genética; Fator de Crescimento Neural/metabolismo; Receptor Nicotínico de Acetilcolina alfa7/metabolismo; Proteínas tau/genética; Proteínas tau/metabolismo

Palavras-chave

APP; Alzheimer's disease; Cholinergic markers; NGF; OMI/HTRA2; α7 nicotinic acetylcholine receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Acetilcolina / Doença de Alzheimer / Serina Peptidase 2 de Requerimento de Alta Temperatura A Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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