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Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression.
Liu, Si Yan; Zhang, Dong Dong; Wu, Yang Fang; Luo, Huang Huang; Jiang, Guang Mei; Xu, Yao; Wu, Yue; Xia, Xun; Wei, Wei; Hu, Bo; Hu, Peng.
Afiliação
  • Liu SY; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Zhang DD; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Wu YF; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Luo HH; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Jiang GM; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Xu Y; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Wu Y; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Xia X; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Wei W; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Hu B; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Hu P; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Int J Mol Med ; 43(1): 535-546, 2019 Jan.
Article em En | MEDLINE | ID: mdl-30365152
The purpose of the present study was to determine whether fibroblast growth factor (FGF)­23 could serve as a novel biomarker for renal osteodystrophy (ROD) progression. A rat model of ROD was induced by left nephrectomy plus intravenous injection of Adriamycin. Serum FGF­23 was determined using an enzyme­linked immunosorbent assay. Serum level and bone expression of FGF­23 were both significantly elevated in the ROD group at 24 h post­surgery. Serum FGF­23 was negatively correlated with calcium, phosphate, 25­hydroxyvitamin D, conventional bone biomarkers and bone collagen X. More importantly, serum FGF­23 was significantly associated with abnormalities in bone formation rate, osteoblasts, osteoclasts, trabecular volume thickness and osteoid volume. Therefore, FGF­23 may serve as a novel biomarker for ROD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Distúrbio Mineral e Ósseo na Doença Renal Crônica / Progressão da Doença / Fatores de Crescimento de Fibroblastos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Distúrbio Mineral e Ósseo na Doença Renal Crônica / Progressão da Doença / Fatores de Crescimento de Fibroblastos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article