Hormonal regulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: kinetic models.
FEBS Lett
; 217(2): 212-5, 1987 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-3036579
ABSTRACT
A graphical method to reveal the so-called 'critical fragments' in schemes of biochemical systems is considered. These fragments produce multiple steady states or self-oscillations in systems. As an example, the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, regulated by glucagon through enzyme phosphorylation, is discussed. It is shown that this enzyme may act as a metabolic switching mechanism in discontinuous or oscillatory regimes, depending on the specific structure of its kinetic scheme. The boundaries of concentrational and parameter domains for these critical phenomena are also predicted.
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Base de dados:
MEDLINE
Assunto principal:
Fosfotransferases
/
Glucagon
/
Monoéster Fosfórico Hidrolases
/
Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article