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Sex steroids in serum and prostatic tissue of human cancerous prostate (STERKPROSER trial).
Meunier, Matthias E; Neuzillet, Yann; Raynaud, Jean-Pierre; Radulescu, Camelia; Ghoneim, Tarek; Fiet, Jean; Giton, Franck; Rouanne, Mathieu; Dreyfus, Jean-François; Lebret, Thierry; Botto, Henry.
Afiliação
  • Meunier ME; Department of Urology, University of Versailles-Saint-Quentin-en-Yvelines, Foch Hospital, Suresnes, France.
  • Neuzillet Y; Department of Urology, University of Versailles-Saint-Quentin-en-Yvelines, Foch Hospital, Suresnes, France.
  • Raynaud JP; University Pierre et Marie Curie, Paris, France.
  • Radulescu C; Department of Pathology, Foch Hospital, Suresnes, France.
  • Ghoneim T; Department of Urology, University of Versailles-Saint-Quentin-en-Yvelines, Foch Hospital, Suresnes, France.
  • Fiet J; INSERM U955, Eq07, Centre de Recherches Chirurgicales, Créteil, France.
  • Giton F; INSERM U955, Eq07, Centre de Recherches Chirurgicales, Créteil, France.
  • Rouanne M; Department of Urology, University of Versailles-Saint-Quentin-en-Yvelines, Foch Hospital, Suresnes, France.
  • Dreyfus JF; Department of Clinical Research and Innovations, University of Versailles-Saint-Quentin-en-Yvelines, Foch Hospital, Suresnes, France.
  • Lebret T; Department of Urology, University of Versailles-Saint-Quentin-en-Yvelines, Foch Hospital, Suresnes, France.
  • Botto H; Department of Urology, University of Versailles-Saint-Quentin-en-Yvelines, Foch Hospital, Suresnes, France.
Prostate ; 79(3): 272-280, 2019 02.
Article em En | MEDLINE | ID: mdl-30370569
ABSTRACT

BACKGROUND:

Currently, there is no consensus regarding the expected concentration levels of intra-prostatic sex steroids in patients with Prostate Cancer (PCa). Our objective was to assess the concentration levels of sex steroids in prostatic tissue and serum, in two cohorts of patients with localized PCa or benign prostatic hyperplasia (BPH).

METHODS:

Between September 2014 and January 2017, men selected for radical cystectomy (for bladder cancer) or open prostatectomy (for BPH), and men selected for radical prostatectomy for localized PCa were included. Blood samples were collected at baseline before surgery, and steroid concentrations were assessed following the recommendations of the Endocrine Society. Intra-prostatic samples were collected from fresh surgical samples, and assessed by gas chromatography and mass spectrometry (GC/MS). Permanova analysis was performed. Analyses were adjusted for age, prostate weight, and prostate-specific antigen (PSA) level.

RESULTS:

A total of 73 patients (41 patients with PCa and 32 patients with BPH) were included in this study. Patients with PCa were younger, and had smaller prostate volumes with higher levels of PSA. The levels of Total Testosterone (TT), Di-Hydro-Testosterone (DHT), and Estradiol (E2) in the serum were not significantly different between PCa and BPH. In PCa tissue, TT concentrations were significantly lower (0.11 ng/g vs 0.47 ng/g, P = 0.0002), however its derivative E2 had significantly higher concentrations (31.0 ng/g vs 22.3 ng/g, P = 0.01). DHT tissue concentrations were not significantly different between the two groups (5.55 ng/g vs 5.42 ng/g, P = 0.70). Intra-prostatic TT concentrations were significantly lower in the peripheral zone than in the central zone for the CaP group (0.07 ng/g vs 0.15 ng/g, P = 0.004).

CONCLUSIONS:

Patients with PCa had lower intra-prostatic TT and higher E2 concentrations levels compared to the patients with BPH. PCa seem to consume more TT and produce more E2, especially in the peripheral zone.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Hormônios Esteroides Gonadais Limite: Aged / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Hormônios Esteroides Gonadais Limite: Aged / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article