Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11.

Spiliotopoulos, Anastasios; Blokpoel Ferreras, Lia; Densham, Ruth M; Caulton, Simon G; Maddison, Ben C; Morris, Joanna R; Dixon, James E; Gough, Kevin C; Dreveny, Ingrid

Spiliotopoulos, Anastasios; Blokpoel Ferreras, Lia; Densham, Ruth M; Caulton, Simon G; Maddison, Ben C; Morris, Joanna R; Dixon, James E; Gough, Kevin C; Dreveny, Ingrid.

Afiliação

Spiliotopoulos A; From the Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD.
Blokpoel Ferreras L; the School of Veterinary Medicine and Science, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire LE12 5RD.
Densham RM; From the Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD.
Caulton SG; the Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, Medical and Dental Schools, University of Birmingham, Birmingham B15 2TT, and.
Maddison BC; From the Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD.
Morris JR; ADAS, School of Veterinary Medicine and Science, Bonington Campus, College Road, Sutton Bonington, Leicestershire LE12 5RD, United Kingdom.
Dixon JE; the Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, Medical and Dental Schools, University of Birmingham, Birmingham B15 2TT, and.
Gough KC; From the Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD.
Dreveny I; the School of Veterinary Medicine and Science, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire LE12 5RD, kevin.gough@nottingham.ac.uk.

J Biol Chem ; 294(2): 424-436, 2019 01 11.

Article em En | MEDLINE | ID: mdl-30373771

Assuntos

Peptídeos/química; Peptídeos/metabolismo; Tioléster Hidrolases/química; Tioléster Hidrolases/metabolismo; Sequência de Aminoácidos; Animais; Sítios de Ligação; Linhagem Celular; Cristalografia por Raios X; Reparo do DNA; Recombinação Homóloga; Humanos; Cinética; Ligantes; Camundongos; Dados de Sequência Molecular; Peptídeos/genética; Domínios Proteicos; Tioléster Hidrolases/genética; Ubiquitina/química; Ubiquitina/metabolismo; Ubiquitinação

Palavras-chave

DNA damage response; USP11; cell-penetrating peptide (CPP); crystal structure; deubiquitylation (deubiquitination); molecular recognition; peptide interaction; peptides; phage display; protease; ubiquitin; ubiquitin-dependent protease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Tioléster Hidrolases Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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