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Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity.
Knier, Benjamin; Hiltensperger, Michael; Sie, Christopher; Aly, Lilian; Lepennetier, Gildas; Engleitner, Thomas; Garg, Garima; Muschaweckh, Andreas; Mitsdörffer, Meike; Koedel, Uwe; Höchst, Bastian; Knolle, Percy; Gunzer, Matthias; Hemmer, Bernhard; Rad, Roland; Merkler, Doron; Korn, Thomas.
Afiliação
  • Knier B; Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Hiltensperger M; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Sie C; Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Aly L; Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Lepennetier G; Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Engleitner T; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Garg G; Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Muschaweckh A; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Mitsdörffer M; Institute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich, Munich, Germany.
  • Koedel U; Department of Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Höchst B; Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Knolle P; Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Gunzer M; Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Hemmer B; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Rad R; Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University Munich, Munich, Germany.
  • Merkler D; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Munich, Germany.
  • Korn T; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Munich, Germany.
Nat Immunol ; 19(12): 1341-1351, 2018 12.
Article em En | MEDLINE | ID: mdl-30374128
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been characterized in the context of malignancies. Here we show that PMN-MDSCs can restrain B cell accumulation during central nervous system (CNS) autoimmunity. Ly6G+ cells were recruited to the CNS during experimental autoimmune encephalomyelitis (EAE), interacted with B cells that produced the cytokines GM-CSF and interleukin-6 (IL-6), and acquired properties of PMN-MDSCs in the CNS in a manner dependent on the signal transducer STAT3. Depletion of Ly6G+ cells or dysfunction of Ly6G+ cells through conditional ablation of STAT3 led to the selective accumulation of GM-CSF-producing B cells in the CNS compartment, which in turn promoted an activated microglial phenotype and lack of recovery from EAE. The frequency of CD138+ B cells in the cerebrospinal fluid (CSF) of human subjects with multiple sclerosis was negatively correlated with the frequency of PMN-MDSCs in the CSF. Thus PMN-MDSCs might selectively control the accumulation and cytokine secretion of B cells in the inflamed CNS.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Autoimunidade / Encefalomielite Autoimune Experimental / Células Supressoras Mieloides / Esclerose Múltipla Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Autoimunidade / Encefalomielite Autoimune Experimental / Células Supressoras Mieloides / Esclerose Múltipla Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article