Improving the Enzymatic Stability and the Pharmacokinetics of Oligonucleotides via DNA-Backboned Bottlebrush Polymers.
Nano Lett
; 18(11): 7378-7382, 2018 11 14.
Article
em En
| MEDLINE
| ID: mdl-30376347
ABSTRACT
Herein, we design and synthesize site-specifically PEGylated oligonucleotide hairpins and demonstrate that their ability to undergo hybridization chain reaction is nearly unaffected by the PEGylation. The resulting DNA-backboned bottlebrush polymers with PEG side chains exhibit increased resistance against nucleolytic degradation, enhanced thermal stabilities, and elevated blood retention times in vivo, which collectively pave the way for more therapeutically focused DNA nanostructure designs.
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Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Polietilenoglicóis
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article