Rewiring of one carbon metabolism in Salmonella serves as an excellent live vaccine against systemic salmonellosis.

Datey, Akshay; Shreenivas, Meghanashree; Chandrasekharan, Giridhar; Joseph, Jeswin; Sah, Shivjee; Aluri, Srinivas; Saha, Sankhanil; Varshney, Umesh; Chakravortty, Dipshikha

Datey, Akshay; Shreenivas, Meghanashree; Chandrasekharan, Giridhar; Joseph, Jeswin; Sah, Shivjee; Aluri, Srinivas; Saha, Sankhanil; Varshney, Umesh; Chakravortty, Dipshikha.

Afiliação

Datey A; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India; Department of Aerospace Engineering, Indian Institute of Science, Bangalore, India; Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, India.
Shreenivas M; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India; Undergraduate Programme, Indian Institute of Science, Bangalore, India.
Chandrasekharan G; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Joseph J; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Sah S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Aluri S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Saha S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Varshney U; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India. Electronic address: varshney@iisc.ac.in.
Chakravortty D; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India; Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, India. Electronic address: dipa@iisc.ac.in.

Vaccine ; 36(50): 7715-7727, 2018 11 29.

Article em En | MEDLINE | ID: mdl-30385055

Assuntos

Bacteriemia/prevenção & controle; Redes e Vias Metabólicas/genética; Infecções por Salmonella/prevenção & controle; Vacinas contra Salmonella/imunologia; Salmonella typhimurium/genética; Salmonella typhimurium/metabolismo; Animais; Anticorpos Antibacterianos/sangue; Bacteriemia/patologia; Carga Bacteriana; Carbono/metabolismo; Citocinas/sangue; Modelos Animais de Doenças; Feminino; Formiato-Tetra-Hidrofolato Ligase/genética; Formiato-Tetra-Hidrofolato Ligase/metabolismo; Deleção de Genes; Metilenotetra-Hidrofolato Desidrogenase (NADP)/deficiência; Camundongos Endogâmicos C57BL; Gravidez; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Infecções por Salmonella/patologia; Vacinas contra Salmonella/administração & dosagem; Vacinas contra Salmonella/genética; Salmonella typhimurium/imunologia; Análise de Sobrevida; Resultado do Tratamento; Vacinas Atenuadas/administração & dosagem; Vacinas Atenuadas/genética; Vacinas Atenuadas/imunologia

Palavras-chave

Live attenuated vaccine; Murine model; One-carbon metabolism; Salmonella Typhimurium; Systemic salmonellosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Salmonella / Salmonella typhimurium / Bacteriemia / Vacinas contra Salmonella / Redes e Vias Metabólicas Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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