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Identification of a specific receptor for plasmin on a group A streptococcus.
Infect Immun ; 55(8): 1914-8, 1987 Aug.
Article em En | MEDLINE | ID: mdl-3038753
Certain group A streptococci demonstrate surface receptors that bind selectively to the key fibrinolytic enzyme, plasmin. These bacteria show no reactivity with the zymogen protein plasminogen or with other serine class proteases, such as trypsin or urokinase. Bacterium-bound plasmin retains its ability to cleave synthetic substrates and its ability to hydrolyze a fibrin clot. The bacterium-bound plasmin is not effectively regulated by its physiological regulator, alpha 2-plasmin inhibitor. This study is the first report of a bacterium-associated receptor for plasmin.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus pyogenes / Fibrinolisina / Receptores de Superfície Celular Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 1987 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus pyogenes / Fibrinolisina / Receptores de Superfície Celular Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 1987 Tipo de documento: Article