Loss of VGLL4 suppresses tumor PD-L1 expression and immune evasion.

Wu, Ailing; Wu, Qingzhe; Deng, Yujie; Liu, Yuning; Lu, Jinqiu; Liu, Liansheng; Li, Xiaoling; Liao, Cheng; Zhao, Bin; Song, Hai

Wu, Ailing; Wu, Qingzhe; Deng, Yujie; Liu, Yuning; Lu, Jinqiu; Liu, Liansheng; Li, Xiaoling; Liao, Cheng; Zhao, Bin; Song, Hai.

Afiliação

Wu A; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, China.
Wu Q; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, China.
Deng Y; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, China.
Liu Y; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, China.
Lu J; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, China.
Liu L; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, China.
Li X; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, China.
Liao C; Department of Preclinical Development, Translation Medicine & External Research, Jiangsu Hengrui Medicine CO., LTD., Shanghai, China.
Zhao B; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, China.
Song H; Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, China haisong@zju.edu.cn.

EMBO J ; 38(1)2019 01 03.

Article em En | MEDLINE | ID: mdl-30396996

Assuntos

Antígeno B7-H1/genética; Fatores de Transcrição/genética; Evasão Tumoral/genética; Células A549; Proteínas Adaptadoras de Transdução de Sinal/fisiologia; Animais; Células Cultivadas; Deleção de Genes; Regulação Neoplásica da Expressão Gênica; Células HEK293; Células HeLa; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Nus; Oncogenes/genética; Interferência de RNA; Fatores de Transcrição/fisiologia; Proteínas de Sinalização YAP

Palavras-chave

Hippo; PDL1; VGLL4; cancer immunity; murine syngeneic tumor model

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Evasão Tumoral / Antígeno B7-H1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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