Microsatellite Typing and Resistance Mechanism Analysis of Voriconazole-Resistant Aspergillus flavus Isolates in South Korean Hospitals.
Antimicrob Agents Chemother
; 63(2)2019 02.
Article
em En
| MEDLINE
| ID: mdl-30397064
ABSTRACT
A recent surveillance study in South Korea revealed that 14% (7/50) of Aspergillus flavus clinical isolates had a voriconazole minimum inhibitory concentration of ≥4 µg/ml. Of seven non-wild-type (non-WT) isolates, six ear isolates from four hospitals shared the same microsatellite genotype. None of the non-WT isolates showed cyp51 mutations associated with azole resistance. However, the mean expression levels of efflux pump (MDR2, atrF, and mfs1) and target (cyp51A) genes exhibited significant differences between non-WT and other isolates.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Aspergillus flavus
/
Repetições de Microssatélites
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Voriconazol
/
Antifúngicos
Limite:
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article