Surfactant Free Delivery of Docetaxel by Poly[(R)-3-hydroxybutyrate-(R)-3-hydroxyhexanoate]-Based Polymeric Micelles for Effective Melanoma Treatments.

Luo, Zheng; Jiang, Lu; Ding, Chizhu; Hu, Benhui; Loh, Xian Jun; Li, Zibiao; Wu, Yun-Long

Luo, Zheng; Jiang, Lu; Ding, Chizhu; Hu, Benhui; Loh, Xian Jun; Li, Zibiao; Wu, Yun-Long.

Afiliação

Luo Z; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, P. R. China.
Jiang L; Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore, 138634, Singapore.
Ding C; College of Science, Huazhong Agricultural University, Wuhan, 430074, P. R. China.
Hu B; School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, 211166, P. R. China.
Loh XJ; Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore, 138634, Singapore.
Li Z; Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore, 138634, Singapore.
Wu YL; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, P. R. China.

Adv Healthc Mater ; 7(23): e1801221, 2018 12.

Article em En | MEDLINE | ID: mdl-30398017

Assuntos

Docetaxel/química; Portadores de Fármacos/química; Micelas; Polímeros/química; Ácido 3-Hidroxibutírico/química; Animais; Caproatos/química; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Docetaxel/farmacologia; Docetaxel/uso terapêutico; Portadores de Fármacos/toxicidade; Liberação Controlada de Fármacos; Hemólise/efeitos dos fármacos; Humanos; Melanoma/tratamento farmacológico; Melanoma/patologia; Camundongos; Camundongos Nus; Polietilenoglicóis/química; Proibitinas; Tensoativos/química; Transplante Heterólogo

Palavras-chave

PHB; chemotherapy; docetaxel; drug delivery; micelle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Portadores de Fármacos / Docetaxel / Micelas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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