New Metabolites from Endophytic Fungus Chaetomium globosum CDW7.
Molecules
; 23(11)2018 Nov 04.
Article
em En
| MEDLINE
| ID: mdl-30400338
ABSTRACT
Five metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7. Compounds 1 and 2 were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds 3â»5 were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (3) exhibited antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.97 µg/mL. In vivo test showed that 3 displayed a protective efficacy of 64.3% against rape Sclerotinia rot at the dosage of 200 µg/mL, comparable to that of carbendazim (69.2%).
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Base de dados:
MEDLINE
Assunto principal:
Chaetomium
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article