U500 Disposable Patch Insulin Pump: Results and Discussion of a Veterans Affairs Pilot Study.
J Endocr Soc
; 2(11): 1275-1283, 2018 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-30402591
ABSTRACT
We present a Veterans Affairs-sponsored pilot study of U500 concentrated insulin administered via disposable patch insulin pump (DPIP) vs twice-daily (BID) injections with an insulin pen in a case series format. We conducted a prospective, single-center, randomized, intent-to-treat pilot study. Ten participants were enrolled with poorly controlled diabetes, defined as hemoglobin A1C >8.0 and severe insulin resistance defined as total daily dose >200 units. Participants were randomized in a 11 ratio to either U500 DPIP or U500 BID insulin titration protocols for 14 weeks. A clinical pattern emerged where four participants randomized to the DPIP treatment arm were withdrawn early as the DPIP did not work well for the purpose studied. There was not a statistically significant difference in the rate of hypoglycemia between treatment arms. Based on our clinical experience and results, we argue against the general use of U500 DPIP in clinical practice.
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MEDLINE
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Clinical_trials
/
Guideline
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article