Quantitative proteomic analysis of aqueous humor from patients with drusen and reticular pseudodrusen in age-related macular degeneration.

Baek, Je-Hyun; Lim, Daehan; Park, Kyu Hyung; Chae, Jae-Byoung; Jang, Hyoik; Lee, Jonghyun; Chung, Hyewon

Baek, Je-Hyun; Lim, Daehan; Park, Kyu Hyung; Chae, Jae-Byoung; Jang, Hyoik; Lee, Jonghyun; Chung, Hyewon.

Afiliação

Baek JH; R&D Center for Clinical Mass Spectrometry, Seegene Medical Foundation, Seoul, 04805, South Korea.
Lim D; Department of Ophthalmology, Konkuk University School of Medicine, Konkuk University Medical Center, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea.
Park KH; Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, 13620, South Korea.
Chae JB; Department of Ophthalmology, Konkuk University School of Medicine, Konkuk University Medical Center, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea.
Jang H; Department of Ophthalmology, Konkuk University School of Medicine, Konkuk University Medical Center, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea.
Lee J; Department of Ophthalmology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, 10380, South Korea.
Chung H; Department of Ophthalmology, Konkuk University School of Medicine, Konkuk University Medical Center, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea. hchung@kuh.ac.kr.

BMC Ophthalmol ; 18(1): 289, 2018 Nov 07.

Article em En | MEDLINE | ID: mdl-30404605

Assuntos

Humor Aquoso/metabolismo; Proteínas do Olho/metabolismo; Atrofia Geográfica/metabolismo; Proteoma/metabolismo; Drusas Retinianas/metabolismo; Idoso; Aldeídos/toxicidade; Biomarcadores/metabolismo; Western Blotting; Células Cultivadas; Impedância Elétrica; Ensaio de Imunoadsorção Enzimática; Feminino; Técnica Indireta de Fluorescência para Anticorpo; Atrofia Geográfica/diagnóstico por imagem; Humanos; Masculino; Espectrometria de Massas; Estresse Oxidativo; Fenótipo; Proteômica; Drusas Retinianas/diagnóstico por imagem; Epitélio Pigmentado da Retina/efeitos dos fármacos; Epitélio Pigmentado da Retina/metabolismo; Tomografia de Coerência Óptica

Palavras-chave

Age-related macular degeneration; Complement; Drusen; Reticular pseudodrusen; SWATH-MS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Humor Aquoso / Drusas Retinianas / Proteoma / Proteínas do Olho / Atrofia Geográfica Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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