Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.
Nat Commun
; 9(1): 4674, 2018 11 07.
Article
em En
| MEDLINE
| ID: mdl-30405126
ABSTRACT
The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population, and test for rare variant burdens across six cardiometabolic traits. We identify a role for rare regulatory variation, which has hitherto been missed. We find evidence of rare variant burdens that are independent of established common variant signals (ADIPOQ and adiponectin, P = 4.2 × 10-8; APOC3 and triglyceride levels, P = 1.5 × 10-26), and identify replicating evidence for a burden associated with triglyceride levels in FAM189B (P = 2.2 × 10-8), indicating a role for this gene in lipid metabolism.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Característica Quantitativa Herdável
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Alelos
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Sequenciamento Completo do Genoma
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article