Synthesis of chiral seven-membered ß-substituted lactams via Rh-catalyzed asymmetric hydrogenation.
Org Biomol Chem
; 16(45): 8819-8823, 2018 11 21.
Article
em En
| MEDLINE
| ID: mdl-30406248
Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered ß-substituted α,ß-unsaturated lactams was successfully developed to prepare various chiral seven-membered ß-substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99% ee).
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MEDLINE
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En
Ano de publicação:
2018
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Article