Higher-Order Organization Principles of Pre-translational mRNPs.

Metkar, Mihir; Ozadam, Hakan; Lajoie, Bryan R; Imakaev, Maxim; Mirny, Leonid A; Dekker, Job; Moore, Melissa J

Metkar, Mihir; Ozadam, Hakan; Lajoie, Bryan R; Imakaev, Maxim; Mirny, Leonid A; Dekker, Job; Moore, Melissa J.

Afiliação

Metkar M; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Ozadam H; Program in Systems Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Lajoie BR; Program in Systems Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Imakaev M; Institute for Medical Engineering and Science and Department of Physics, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
Mirny LA; Institute for Medical Engineering and Science and Department of Physics, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
Dekker J; Program in Systems Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA; Howard Hughes Medical Institute, USA. Electronic address: job.dekker@umassmed
Moore MJ; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: melissa.moore@umassmed.edu.

Mol Cell ; 72(4): 715-726.e3, 2018 11 15.

Article em En | MEDLINE | ID: mdl-30415953

Assuntos

Precursores de RNA/ultraestrutura; Ribonucleoproteínas/genética; Ribonucleoproteínas/ultraestrutura; Núcleo Celular; Éxons; Células HEK293; Humanos; Imunoprecipitação/métodos; Processamento de Proteína Pós-Traducional; Precursores de RNA/genética; Splicing de RNA; Estabilidade de RNA; RNA Mensageiro/genética; RNA Mensageiro/ultraestrutura; RNA não Traduzido; Spliceossomos; Transcrição Gênica

Palavras-chave

ChimeraTie; RIPPLiT; exon-junction complex; mRNA; mRNP structure; proximity ligation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ribonucleoproteínas / Precursores de RNA Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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