Mechanisms of HLA-DP Antigen Processing and Presentation Revisited.
Trends Immunol
; 39(12): 960-964, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30416081
ABSTRACT
Polymorphisms in HLA-DP can modulate interactions with the invariant chain chaperone, contributing independently to differences in the peptide repertoire presented on DP. The resulting presentation of intracellular antigens directly to CD4+ T cells may partly explain genetic and clinical studies describing previously unexplained links between polymorphism in DP and disease.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA-DP
/
Apresentação de Antígeno
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article