Icodextrin is Associated with a Lower Risk of Stroke in Peritoneal Dialysis Patients.
Nephron
; 141(2): 112-118, 2019.
Article
em En
| MEDLINE
| ID: mdl-30423579
ABSTRACT
BACKGROUND/AIMS:
This study investigated whether peritoneal dialysis (PD) patients using icodextrin were at a reduced risk of stroke.METHODS:
From Taiwan National Health Insurance data, it was found that there were 6,796 new end-stage renal disease patients undergoing dialysis between 2005 and 2011. We compared the risk of stroke between PD patients with or without icodextrin treatment. The follow-up period began from the date of PD initiation to the end of 2011. The time-dependent Cox proportional hazards regression models were used to analyze the risk of stroke.RESULTS:
Among PD patients, the icodextrin users had both a lower incidence and risk of stroke than icodextrin non-users (incidence 22.4 vs. 25.2/1,000 person-years) with an adjusted hazard ratio of 0.76 (95% CI 0.63-0.93). The results were similar in models considering death a competing risk (overall adjusted subhazard ratio [SHR] 0.78, 95% CI 0.63-0.94). Icodextrin users also had a lower risk of ischemic stroke with or without considering death a competing risk (adjusted SHR 0.71, 95% CI 0.57-0.89 and adjusted HR 0.74, 95% CI 0.59-0.93, respectively), compared to non-users.CONCLUSION:
The use of icodextrin is associated with a lower incidence and risk of stroke in PD patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Soluções para Diálise
/
Diálise Peritoneal
/
Acidente Vascular Cerebral
/
Icodextrina
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
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Humans
/
Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article