NVP-BEZ235 Attenuated Cell Proliferation and Migration in the Squamous Cell Carcinoma of Oral Cavities and p70S6K Inhibition Mimics its Effect.

Hsu, Cheng-Ming; Lin, Pai-Mei; Lin, Hsin-Ching; Tsai, Yao-Te; Tsai, Ming-Shao; Li, Shau-Hsuan; Wu, Ching-Yuan; Yang, Yao-Hsu; Lin, Sheng-Fung; Yang, Ming-Yu

Hsu, Cheng-Ming; Lin, Pai-Mei; Lin, Hsin-Ching; Tsai, Yao-Te; Tsai, Ming-Shao; Li, Shau-Hsuan; Wu, Ching-Yuan; Yang, Yao-Hsu; Lin, Sheng-Fung; Yang, Ming-Yu.

Afiliação

Hsu CM; Department of Otolaryngology, Chiayi Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Chiayi 61363, Taiwan. scm0031@adm.cgmh.org.tw.
Lin PM; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. scm0031@adm.cgmh.org.tw.
Lin HC; Department of Nursing, I-Shou University, Kaohsiung 82445, Taiwan. paimei@isu.edu.tw.
Tsai YT; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. hclin@cgmh.org.tw.
Tsai MS; Department of Otolaryngology, Chiayi Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Chiayi 61363, Taiwan. yaote1215@gmail.com.
Li SH; Department of Otolaryngology, Chiayi Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Chiayi 61363, Taiwan. b87401061@gmail.com.
Wu CY; Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. lee0624@cgmh.org.tw.
Yang YH; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. smbepigwu77@gmail.com.
Lin SF; Department of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan. smbepigwu77@gmail.com.
Yang MY; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. r95841012@adm.cgmh.org.tw.

Int J Mol Sci ; 19(11)2018 Nov 10.

Article em En | MEDLINE | ID: mdl-30423811

Assuntos

Carcinoma de Células Escamosas/patologia; Movimento Celular/efeitos dos fármacos; Imidazóis/farmacologia; Boca/patologia; Inibidores de Proteínas Quinases/farmacologia; Quinolinas/farmacologia; Proteínas Quinases S6 Ribossômicas 70-kDa/antagonistas & inibidores; Adulto; Idoso; Carcinoma de Células Escamosas/genética; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Regulação para Baixo/efeitos dos fármacos; Regulação para Baixo/genética; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Masculino; Pessoa de Meia-Idade; Invasividade Neoplásica; Fosforilação/efeitos dos fármacos; Proteínas Quinases S6 Ribossômicas 70-kDa/metabolismo; Transdução de Sinais/efeitos dos fármacos; Serina-Treonina Quinases TOR/genética; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

NVP-BEZ235; mTOR; oral cavity squamous cell carcinoma (OSCC); p70S6K

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Carcinoma de Células Escamosas / Movimento Celular / Proteínas Quinases S6 Ribossômicas 70-kDa / Inibidores de Proteínas Quinases / Imidazóis / Boca Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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