Neutrophilic figurate erythema of infancy: A diagnostic challenge.
J Cutan Pathol
; 46(3): 216-220, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-30430608
ABSTRACT
Neutrophilic figurate erythema of infancy (NFEI) is a rare variant of annular erythema of infancy. It is characterized by annular erythematous plaques, occasionally with a polycyclic configuration. The main challenge is to differentiate this rare entity from other figurate erythemas associated with serious diseases such as neonatal lupus erythematosus. We present the case of a 9-month-old female admitted with a skin rash of unclear etiology. The rash started on her face at the age of 3 months and gradually spread to her extremities. She had no constitutional symptoms, and her health and development were otherwise unremarkable since birth. This persistent skin eruption consisted of many ill-defined erythematous papules and annular plaques. Histologic examination revealed perivascular neutrophils and eosinophils with abundant nuclear dust without signs of vasculitis. NFEI is a diagnostic enigma both clinically and histologically. Absence of an underlying cause, dermal neutrophilic infiltrate with leukocytoclasis, and lack of vascular damage are the keys to diagnosis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dermatopatias Genéticas
/
Eritema
Tipo de estudo:
Diagnostic_studies
Limite:
Female
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Humans
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Infant
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article