A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium.
Alzheimers Dement
; 15(3): 400-409, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30439333
ABSTRACT
INTRODUCTION:
We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB).METHODS:
In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns.RESULTS:
Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values < .001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features.DISCUSSION:
The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.Palavras-chave
Alzheimer's disease; Dementia; Dementia with Lewy bodies; Differential diagnosis; Hippocampal spearing atrophy pattern; Limbic-predominant atrophy pattern; Magnetic resonance imaging; Medial temporal atrophy; Minimal-atrophy pattern; Neuroimaging; Posterior atrophy frontal atrophy; Typical Alzheimer's disease atrophy pattern
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
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Doença por Corpos de Lewy
Tipo de estudo:
Diagnostic_studies
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Observational_studies
Limite:
Aged
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Female
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Humans
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Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article