Vascular Graft Pressure-Flow Monitoring Using 3D Printed MWCNT-PDMS Strain Sensors.
Annu Int Conf IEEE Eng Med Biol Soc
; 2018: 2989-2992, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-30441026
ABSTRACT
Real-time monitoring of arteriovenous graft blood flow would provide early warning of graft failure to permit interventions such as angioplasty or graft replacement to avoid catastrophic failure. We have developed a new type of flexible pulsation sensor (FPS) consisting of a 3D printed elastic cuff wrapped around a graft and thus not in contact with blood. The FPS uses multi-walled carbon nanotubes (MWCNTs) dispersed in polydimethylsiloxane (PDMS) as a piezoresistive sensor layer, which is embedded within structural thixotropic PDMS. These materials were specifically developed to enable sensor additive manufacturing via 3D Bio-plotting, and the resulting strain sensor is more compliant and has a wider maximum strain range than graft materials. Here, we analyze the strain transduction mechanics on a vascular graft and describe the memristive properties of MWCNT-PDMS composites, which may be mitigated using AC biasing. In vitro testing of the FPS on a vascular graft phantom showed a robust, linear sensor output to pulsatile flows (170-650 mL/min) and pressures (62-175 mmHg). The FPS showed an RMS error when measuring pressure and flow of 7.7 mmHg and 29.3 mL/min, with a mean measurement error of 6.5% (pressure) and 8.0% (flow).
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Base de dados:
MEDLINE
Assunto principal:
Impressão Tridimensional
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article