Analyzing hedyotis diffusa mechanisms of action from the genomics perspective.
Comput Methods Programs Biomed
; 174: 1-8, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-30442470
ABSTRACT
BACKGROUND AND OBJECTIVE:
Hedyotis diffusa is an herb used for anti-cancer, anti-oxidant, anti-inflammatory, and anti-fibroblast treatment in the clinical practice of Traditional Chinese Medicine. However, its pharmacological mechanisms have not been fully established and there is a lack of modern scientific verification. One of the best ways to further understand Hedyotis diffusa's mechanisms of action is to analyze it from the genomics perspective.METHODS:
In this study, we used network pharmacology approaches to infer the herb-gene interactions, the herb-pathway interactions, and the gene families. We then analyzed Hedyotis diffusa's mechanisms of action using the genomics context combined with the Traditional Chinese Medicine clinical practice and the pharmacological research.RESULTS:
The results obtained in the pathway and gene family analysis were consistent with the Traditional Chinese Medicine clinical experience and the pharmacological activities of Hedyotis diffusa.CONCLUSIONS:
Our approach can identify related genes and pathways correctly with little a priori knowledge, and provide potential directions to facilitate further research.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Apoptose
/
Genômica
/
Hedyotis
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article