Study on the drug permeation mechanism from flurbiprofen-loaded glyceryl monooleyl ether-based lyotropic liquid crystalline nanoparticles across the skin: Synchrotron X-ray diffraction and confocal laser scanning microscopy study.

Uchino, Tomonobu; Kato, Sayaka; Hatta, Ichiro; Miyazaki, Yasunori; Suzuki, Tomonori; Sasaki, Kohta; Kagawa, Yoshiyuki

Uchino, Tomonobu; Kato, Sayaka; Hatta, Ichiro; Miyazaki, Yasunori; Suzuki, Tomonori; Sasaki, Kohta; Kagawa, Yoshiyuki.

Afiliação

Uchino T; Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: uchinot@u-shizhuoka-ken.ac.jp.
Kato S; Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Hatta I; Department of Research, Nagoya Industrial Science Research Institute, 1-13 Yotsuyadori, Chikusa-ku, Nagoya 464-0819, Japan.
Miyazaki Y; Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Suzuki T; Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Sasaki K; Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Kagawa Y; Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

Int J Pharm ; 555: 259-269, 2019 Jan 30.

Article em En | MEDLINE | ID: mdl-30447335

Assuntos

Flurbiprofeno/administração & dosagem; Cristais Líquidos; Nanopartículas; Absorção Cutânea; Animais; Anti-Inflamatórios não Esteroides/administração & dosagem; Anti-Inflamatórios não Esteroides/farmacocinética; Química Farmacêutica/métodos; Liberação Controlada de Fármacos; Álcoois Graxos/química; Fluorescência; Flurbiprofeno/farmacocinética; Masculino; Camundongos; Camundongos Pelados; Microscopia Confocal; Pele/metabolismo; Síncrotrons

Palavras-chave

Confocal laser scanning microscopy; Flurbiprofen; Liquid crystalline nanoparticles; Skin permeation; Stratum corneum; X-ray diffraction

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Absorção Cutânea / Flurbiprofeno / Cristais Líquidos / Nanopartículas Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google