Decomposition of Piloty's acid derivatives - Toward the understanding of factors controlling HNO release.
Arch Biochem Biophys
; 661: 132-144, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30448388
ABSTRACT
The recent interest in the clinical applications of Piloty's acid derivatives as HNO donors for the treatment of cardiovascular system dysfunction has led us to the examination of factors controlling HNO release from selected ortho-substituted N-hydroxysulfonamides. Here we present the kinetic and quantum mechanical studies on the mechanism of HNO release from selected ortho-substituted N-hydroxysulfonamides and in vivo examination of the antiaggregatory properties of N-hydroxy-(2-bromobenzene)sulfonamide complex with sodium salt of ß-cyclodextrin sulfobutyl ethers-ethyl ethers as compared with Angeli's salt.
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Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Ácidos Hidroxâmicos
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Nitritos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article