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Mechanisms of Granulocytopoiesis Recovery Stimulation with Filgrastim in Breast Cancer Patients Receiving Chemotherapy.
Goldberg, V E; Polyakova, T Yu; Popova, N O; Vysotskaya, V V; Simolina, E I; Dudnikova, E A; Goncharova, N M; Belevich, Yu V; Tuzikova, T P; Goldberg, A V; Miroshnichenko, L A; Udut, E V; Simanina, E V; Zyuz'kov, G N; Zhdanov, V V; Dygai, A M.
Afiliação
  • Goldberg VE; Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia. center@tnimc.ru.
  • Polyakova TY; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Popova NO; National Research Tomsk State University, Tomsk, Russia.
  • Vysotskaya VV; Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Simolina EI; Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Dudnikova EA; Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Goncharova NM; Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Belevich YV; Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Tuzikova TP; Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Goldberg AV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Miroshnichenko LA; Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Udut EV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Simanina EV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Zyuz'kov GN; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Zhdanov VV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
  • Dygai AM; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
Bull Exp Biol Med ; 166(1): 63-68, 2018 Nov.
Article em En | MEDLINE | ID: mdl-30450524
We studied myelotoxicity of modern schemes of chemotherapy for breast cancer (docetaxel/doxorubicin and cyclophosphamide/doxorubicin/5-fluorouracil) towards granulocytopoiesis, the mechanisms determining the differences of hematological effects of these schemes, and the efficiency of correction of the observed changes with granulocyte CSF (filgrastim). Granulocytopoiesis stimulation with filgrastim during the treatment with docetaxel/doxorubicin combination was more pronounced than during cyclophosphamide/doxorubicin/5-fluorouracil therapy. The observed differences were found at all levels of granulocyte lineage organization (central and peripheral), which is related to different effects of the cytostatic substances used in the proposed protocols on the structures controlling hemopoiesis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Filgrastim / Granulócitos Tipo de estudo: Guideline Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Filgrastim / Granulócitos Tipo de estudo: Guideline Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article