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Effect of matrine on reducing damage to bovine mammary epithelial cells induced by Staphylococcus aureus alpha-hemolysin.
Feng, F; Wa, M M; Luo, H X; Guan, C P; Zhou, X Z.
Afiliação
  • Feng F; Key lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, Department of College of Life Science, Ningxia University, Helanshan Road No. 539, Yinchuan, Ningxia, 750021, P. R. China.
  • Wa MM; Key lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, Department of College of Life Science, Ningxia University, Helanshan Road No. 539, Yinchuan, Ningxia, 750021, P. R. China.
  • Luo HX; Key lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, Department of College of Life Science, Ningxia University, Helanshan Road No. 539, Yinchuan, Ningxia, 750021, P. R. China.
  • Guan CP; Key lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, Department of College of Life Science, Ningxia University, Helanshan Road No. 539, Yinchuan, Ningxia, 750021, P. R. China.
  • Zhou XZ; Key lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, Department of College of Life Science, Ningxia University, Helanshan Road No. 539, Yinchuan, Ningxia, 750021, P. R. China.
Pol J Vet Sci ; 21(2): 409-413, 2018 Jun.
Article em En | MEDLINE | ID: mdl-30450884
Taking bacterial virulence factors as targets is a new therapy for treating host bacterial infection. The aim of this study was to investigate the effect of matrine on α-hemolysin production of Staphylococcus aureus (S. aureus) and reducing the damage to bovine mammary epithelial cells (BMECs) induced by S. aureus α-hemolysin. Subinhibitory concentrations of matrine decreased the production of α-hemolysin in none dose-dependent manner and matrine exhibited a protective effect on S. aureus-induced BMECs injury. The results indicated that the structure of matrine may potentially be used as a basic structure for development of drugs aimed at curing and preventing dairy bovine mastitis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolizinas / Infecções Estafilocócicas / Staphylococcus aureus / Alcaloides / Células Epiteliais / Proteínas Hemolisinas Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolizinas / Infecções Estafilocócicas / Staphylococcus aureus / Alcaloides / Células Epiteliais / Proteínas Hemolisinas Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article