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Diphenyl Ethers from a Marine-Derived Aspergillus sydowii.
Wang, Ya-Nan; Mou, Yan-Hua; Dong, Yu; Wu, Yan; Liu, Bing-Yu; Bai, Jian; Yan, Dao-Jiang; Zhang, Le; Feng, Dan-Qing; Pei, Yue-Hu; Hu, You-Cai.
Afiliação
  • Wang YN; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. wangyanan@imm.ac.cn.
  • Mou YH; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China. mu_hua_jj@sina.com.
  • Dong Y; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China. allenn7@foxmail.com.
  • Wu Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. allenn7@foxmail.com.
  • Liu BY; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. wuyan@imm.ac.cn.
  • Bai J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. liubingyu@imm.ac.cn.
  • Yan DJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. baijian@imm.ac.cn.
  • Zhang L; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. yandj@imm.ac.cn.
  • Feng DQ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. zhangle@imm.ac.cn.
  • Pei YH; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen 361102, China. dqfeng@xmu.edu.cn.
  • Hu YC; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China. peiyueh@vip.163.com.
Mar Drugs ; 16(11)2018 Nov 16.
Article em En | MEDLINE | ID: mdl-30453472
Six new diphenyl ethers (1⁻6) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived Aspergillus sydowii guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds 1 and 2 are rare diphenyl ether glycosides containing d-ribose. The absolute configuration of the sugar moieties in compounds 1⁻3 was determined by a LC-MS method. All the compounds were evaluated for their cytotoxicities against eight cancer cell lines, including 4T1, U937, PC3, HL-60, HT-29, A549, NCI-H460, and K562, and compounds 1, 5, 6, and 8⁻11 were found to exhibit selective cytotoxicity against different cancer cell lines.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Éteres Fenílicos / Aspergillus / Organismos Aquáticos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Éteres Fenílicos / Aspergillus / Organismos Aquáticos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article