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Virtual Hepatic Venous Pressure Gradient with CT Angiography (CHESS 1601): A Prospective Multicenter Study for the Noninvasive Diagnosis of Portal Hypertension.
Qi, Xiaolong; An, Weimin; Liu, Fuquan; Qi, Ruizhao; Wang, Lei; Liu, Yanna; Liu, Chuan; Xiang, Yi; Hui, Jialiang; Liu, Zhao; Qi, Xingshun; Liu, Changchun; Peng, Baogang; Ding, Huiguo; Yang, Yongping; He, Xiaoshun; Hou, Jinlin; Tian, Jie; Li, Zhiwei.
Afiliação
  • Qi X; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • An W; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Liu F; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Qi R; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Wang L; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Liu Y; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Liu C; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Xiang Y; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Hui J; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Liu Z; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Qi X; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Liu C; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Peng B; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Ding H; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Yang Y; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • He X; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Hou J; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Tian J; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
  • Li Z; From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chu
Radiology ; 290(2): 370-377, 2019 02.
Article em En | MEDLINE | ID: mdl-30457484
ABSTRACT
Purpose To develop and validate a computational model for estimating hepatic venous pressure gradient (HVPG) based on CT angiographic images, termed virtual HVPG, to enable the noninvasive diagnosis of portal hypertension in patients with cirrhosis. Materials and Methods In this prospective multicenter diagnostic trial (ClinicalTrials.gov identifier NCT02842697), 102 consecutive eligible participants (mean age, 47 years [range, 21-75 years]; 68 men with a mean age of 44 years [range, 21-73 years] and 34 women with a mean age of 52 years [range, 24-75 years]) were recruited from three high-volume liver centers between August 2016 and April 2017. All participants with cirrhosis of various causes underwent transjugular HVPG measurement, Doppler US, and CT angiography. Virtual HVPG was developed with a three-dimensional reconstructed model and computational fluid dynamics. Results In the training cohort (n = 29), the area under the receiver operating characteristic curve (AUC) of virtual HVPG in the prediction of clinically significant portal hypertension (CSPH) was 0.83 (95% confidence interval [CI] 0.58, 1.00). The diagnostic performance was prospectively confirmed in the validation cohort (n = 73), with an AUC of 0.89 (95% CI 0.81, 0.96). Inter- and intraobserver agreement was 0.88 and 0.96, respectively, suggesting the good reproducibility of virtual HVPG measurements. There was good correlation between virtual HVPG and invasive HVPG (R = 0.61, P < .001), with a satisfactory performance to rule out (7.3 mm Hg) and rule in (13.0 mm Hg) CSPH. Conclusion The accuracy of a computational model of virtual hepatic venous pressure gradient (HVPG) shows significant correlation with invasive HVPG. The virtual HVPG also showed a good performance in the noninvasive diagnosis of clinically significant portal hypertension in cirrhosis. © RSNA, 2018 Online supplemental material is available for this article. See also the editorial by Malayeri in this issue.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interpretação de Imagem Assistida por Computador / Pressão na Veia Porta / Angiografia por Tomografia Computadorizada / Hipertensão Portal Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interpretação de Imagem Assistida por Computador / Pressão na Veia Porta / Angiografia por Tomografia Computadorizada / Hipertensão Portal Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article