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Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.
Wahl, Devin; Solon-Biet, Samantha M; Wang, Qiao-Ping; Wali, Jibran A; Pulpitel, Tamara; Clark, Ximonie; Raubenheimer, David; Senior, Alistair M; Sinclair, David A; Cooney, Gregory J; de Cabo, Rafael; Cogger, Victoria C; Simpson, Stephen J; Le Couteur, David G.
Afiliação
  • Wahl D; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Centre for Education and Research on Ageing, Concord, NSW 2139, Australia.
  • Solon-Biet SM; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
  • Wang QP; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China.
  • Wali JA; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
  • Pulpitel T; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
  • Clark X; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
  • Raubenheimer D; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
  • Senior AM; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia; School of Mathematics and Statistics, The University of Sydney, NSW 2006, Australia.
  • Sinclair DA; Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia.
  • Cooney GJ; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
  • de Cabo R; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
  • Cogger VC; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Centre for Education and Research on Ageing, Concord, NSW 2139, Australia.
  • Simpson SJ; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: stephen.simpson@sydney.edu.au.
  • Le Couteur DG; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Centre for Education and Research on Ageing, Concord, NSW 2139, Australia. Electronic address: david.lecouteur@sydney.edu.au.
Cell Rep ; 25(8): 2234-2243.e6, 2018 11 20.
Article em En | MEDLINE | ID: mdl-30463018
ABSTRACT
Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-protein, high-carbohydrate (LPHC) diets also extend lifespan, but it is not known whether they are beneficial for brain health. We compared hippocampus biology and memory in mice subjected to 20% CR or provided ad libitum access to one of three LPHC diets or to a control diet. Patterns of RNA expression in the hippocampus of 15-month-old mice were similar between mice fed CR and LPHC diets when we looked at genes associated with longevity, cytokines, and dendrite morphogenesis. Nutrient-sensing proteins, including SIRT1, mTOR, and PGC1α, were also influenced by diet; however, the effects varied by sex. CR and LPHC diets were associated with increased dendritic spines in dentate gyrus neurons. Mice fed CR and LPHC diets had modest improvements in the Barnes maze and novel object recognition. LPHC diets recapitulate some of the benefits of CR on brain aging.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Envelhecimento / Carboidratos da Dieta / Dieta com Restrição de Proteínas Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Envelhecimento / Carboidratos da Dieta / Dieta com Restrição de Proteínas Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article