Metal-free Chlorothiolation of Alkenes using HCl and Sulfoxides.
European J Org Chem
; 2018(34): 4705-4708, 2018 Sep 16.
Article
em En
| MEDLINE
| ID: mdl-30467455
ABSTRACT
We report a novel method for the chlorothiolation of alkenes using HCl and sulfoxides to achieve the 1,2-difunctionalization of unactivated alkenes. The combination of our new HCl reagent (HCl/DMPU) with sulfoxides forms a unique chlorothiolation system. Both terminal and internal alkenes are suitable substrates. This method works at gram scale and is applicable in further synthetic elaborations.
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MEDLINE
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En
Ano de publicação:
2018
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Article