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Disease caused by non-tuberculous mycobacteria in children with cystic fibrosis.
Lu, Mimi; Saddi, Vishal; Britton, Philip N; Selvadurai, Hiran; Robinson, Paul D; Pandit, Chetan; Marais, Ben J; Fitzgerald, Dominic A.
Afiliação
  • Lu M; Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia. Electronic address: Mimi.lu1@health.nsw.gov.au.
  • Saddi V; Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia.
  • Britton PN; Department of Infectious Diseases, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
  • Selvadurai H; Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
  • Robinson PD; Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
  • Pandit C; Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
  • Marais BJ; Department of Infectious Diseases, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
  • Fitzgerald DA; Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Paediatr Respir Rev ; 29: 42-52, 2019 Feb.
Article em En | MEDLINE | ID: mdl-30473423
ABSTRACT
Non-tuberculous mycobacterial (NTM) (especially M. abscessus complex) infections pose a considerable challenge in the management of lung disease in patients with cystic fibrosis (CF). The apparent increase in prevalence is likely multifactorial. Emergent evidence of patient-to-patient transmission and isolation of highly resistant strains is a concern for all CF centers around the world. Treatment is often long and burdensome with multiple agents. Treatment side effects are frequent and can cause significant morbidity. Although consensus guidelines provide some direction, many units are faced with the challenges of finding drug combinations for highly resistant strains; dealing with interruptions of treatment; discussing additional facilitating procedures in the form of gastrostomy and long-term vascular access devices; as well as supporting families emotionally and psychologically through the process.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Cística / Infecções por Mycobacterium não Tuberculosas Tipo de estudo: Diagnostic_studies / Guideline / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Cística / Infecções por Mycobacterium não Tuberculosas Tipo de estudo: Diagnostic_studies / Guideline / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article