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Recent advances in gold-NHC complexes with biological properties.
Mora, Malka; Gimeno, M Concepción; Visbal, Renso.
Afiliação
  • Mora M; Departamento de Ciencias Naturales y Exactas, Universidad de la Costa, c/58 no. 55-66, 080002 Barranquilla, Colombia. rvisbal4@cuc.edu.co.
  • Gimeno MC; Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza, Spain. gimeno@unizar.es.
  • Visbal R; Departamento de Ciencias Naturales y Exactas, Universidad de la Costa, c/58 no. 55-66, 080002 Barranquilla, Colombia. rvisbal4@cuc.edu.co and Departamento de Gestión Industrial, Agroindustrial y Operaciones, c/58 no. 55-66, 080002 Barranquilla, Colombia.
Chem Soc Rev ; 48(2): 447-462, 2019 Jan 21.
Article em En | MEDLINE | ID: mdl-30474097
This tutorial review covers the recent advances made in the study of gold complexes containing N-heterocyclic carbene ligands with biological properties. The great stability, ease of modulation of the electronic properties and excellent σ-donating capacity displayed by NHCs allow gold-NHC derivatives to reach high stability in biological media and relatively good internalization into cells and for that they have emerged as excellent potential chemotherapeutics. The new gold-NHC derivatives show superior anticancer activity compared to other standards such as Cisplatin or Auranofin. In addition, the application of gold-NHC complexes in the treatment of other human diseases as antibacterial, antioxidant and antiparasitic agents is reviewed for the first time.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexos de Coordenação / Ouro / Metano Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexos de Coordenação / Ouro / Metano Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article