Autophagy and the cell biology of age-related disease.
Nat Cell Biol
; 20(12): 1338-1348, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30482941
Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Envelhecimento
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Senescência Celular
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Doenças Neurodegenerativas
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Cardiomiopatias
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article