HLA-B*44:138Q: Evidence for a confined deletion and recombination events in an otherwise unaffected HLA-haplotype.
HLA
; 93(2-3): 89-96, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30488584
ABSTRACT
We discovered a new HLA-B allele, HLA-B*44138Q, and confirmed its segregation. For characterisation, we used serology, sequence specific oligonucleotide (SSO), sequence specific primer (SSP), and full length sequencing by Sanger and next-generation sequencing. From an evolutionary point the 5' part of the new allele is identical with alleles from the HLA-B*4402 group, while its 3' part is identical to the HLA-B*15180102 allele, the breakpoint being located somewhere between intron 3 and exon 4. The salient feature of the new allele is a deletion of codon 94 in exon 3, which is unique for HLA-alleles reported so far. Gene conversion can be hypothesised in the generation of this HLA sequence; however, the deletion seems to have occurred additionally. Other HLA-alleles of the new allele's haplotype were common alleles.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Recombinação Genética
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Haplótipos
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Antígenos HLA-B
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Deleção de Genes
Limite:
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article