Professional and 'Amateur' Antigen-Presenting Cells In Type 2 Immunity.
Trends Immunol
; 40(1): 22-34, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30502024
ABSTRACT
Dendritic cells (DCs) are critical for the activation of naïve CD4+ T cells and are considered professional antigen-presenting cells (APCs), as are macrophages and B cells. Recently, several innate type 2 immune cells, such as basophils, mast cells (MCs), eosinophils, and innate type 2 lymphocytes (ILC2), have also emerged as harboring APC behavior. Through surface expression or transfer of peptide-loaded MHCII, expression of costimulatory and co-inhibitory molecules, as well as the secretion of polarizing cytokines, these innate cells can extensively communicate with effector and regulatory CD4+ T cells. An exciting new concept is that the complementary tasks of these 'amateur' APCs contribute to shaping and regulating adaptive immunity to allergens and helminths, often in collaboration with professional APCs.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos
/
Imunidade Adaptativa
/
Células Apresentadoras de Antígenos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article