Fatigue at enrollment predicts EDSS worsening in the New York State Multiple Sclerosis Consortium.
Mult Scler
; 26(1): 99-108, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-30507270
ABSTRACT
BACKGROUND:
Fatigue is one of the most common and distressing symptoms among persons with multiple sclerosis (pwMS).OBJECTIVE:
The aim of this study is to evaluate fatigue as a predictor for disease worsening among pwMS.METHODS:
In this retrospective cohort study of New York State MS Consortium (NYSMSC) registry, MS patients reporting moderate-to-severe fatigue at study enrollment (n = 2714) were frequency matched to less-fatigued subjects (n = 2714) on age, baseline Kurtzke Expanded Disability Status Scale (EDSS), disease duration, and MS phenotype. Change from baseline patient-reported outcomes (PROs), as measured by LIFEware™, categorized participants into two groups those with stable/improved outcomes and those who worsened. In a subgroup of patients with longitudinal data (n = 1951), sustained EDSS worsening was analyzed using Cox proportional hazards modeling to explore the effect of fatigue.RESULTS:
The median survival time from study enrollment to sustained EDSS worsening was 8.7 years (CI 7.2-10.1). Participants who reported fatigue at baseline were more likely to experience sustained EDSS worsening during follow-up (HR 1.4, 95% CI 1.2-1.7). Patients who were fatigued at baseline were also more likely to report worsening psychosocial limitations (all ps ⩽ 0.01).CONCLUSION:
In addition to being a common symptom of MS, severe fatigue was a significant predictor for EDSS worsening in the NYSMSC.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
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Sistema de Registros
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Progressão da Doença
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Fadiga
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Medidas de Resultados Relatados pelo Paciente
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Esclerose Múltipla
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article