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High Abundance of genus Prevotella in the gut of perinatally HIV-infected children is associated with IP-10 levels despite therapy.
Kaur, Urvinder S; Shet, Anita; Rajnala, Niharika; Gopalan, Bindu Parachalil; Moar, Preeti; D, Himanshu; Singh, Balendra Pratap; Chaturvedi, Rupesh; Tandon, Ravi.
Afiliação
  • Kaur US; Laboratory of AIDS Research and Immunology, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
  • Shet A; International Vaccine Access Center, Johns Hopkins School of Public Health, Baltimore, USA.
  • Rajnala N; Division of Infectious Diseases, St. John's Research Institute, St. John's National Academy of health Sciences, Bangalore, India.
  • Gopalan BP; Division of Infectious Diseases, St. John's Research Institute, St. John's National Academy of health Sciences, Bangalore, India.
  • Moar P; Laboratory of AIDS Research and Immunology, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
  • D H; Department of Medicine, King Georges Medical University, Lucknow, India.
  • Singh BP; Department of Prosthodontics, King Georges Medical University, Lucknow, India.
  • Chaturvedi R; Host Pathogen Interaction Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
  • Tandon R; Laboratory of AIDS Research and Immunology, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India. ravitandon@jnu.ac.in.
Sci Rep ; 8(1): 17679, 2018 12 05.
Article em En | MEDLINE | ID: mdl-30518941
Perinatal HIV infection is characterized by faster HIV disease progression and higher initial rate of HIV replication compared to adults. While antiretroviral therapy (ART) has greatly reduced HIV replication to undetectable levels, there is persistent elevated inflammation associated with HIV disease progression. Alteration of gut microbiota is associated with increased inflammation in chronic adult HIV infection. Here, we aim to study the gut microbiome and its role in inflammation in treated and untreated HIV-infected children. Examination of fecal microbiota revealed that perinatally infected children living with HIV had significantly higher levels of genus Prevotella that persisted despite ART. These children also had higher levels of soluble CD14 (sCD14), a marker of microbial translocation, and IP-10 despite therapy. The Prevotella positively correlated with IP-10 levels in both treated and untreated HIV-infected children, while genus Prevotella and species Prevotella copri was inversely associated with CD4 count. Relative abundance of genus Prevotella and species Prevotella copri showed positive correlation with sCD14 in ART-suppressed perinatally HIV-infected children. Our study suggests that gut microbiota may serve as one of the driving forces behind the persistent inflammation in children despite ART. Reshaping of microbiota using probiotics may be recommended as an adjunctive therapy along with ART.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Prevotella / Terapia Antirretroviral de Alta Atividade / Quimiocina CXCL10 / Microbioma Gastrointestinal Tipo de estudo: Risk_factors_studies Limite: Child / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Prevotella / Terapia Antirretroviral de Alta Atividade / Quimiocina CXCL10 / Microbioma Gastrointestinal Tipo de estudo: Risk_factors_studies Limite: Child / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article